Research 

& Products

We do research in an interdisciplinary field of Sensing Technology, Nano-Biotechnology, and Material Science to provide pertinent solutions to healthcare

The lab research-interest focuses on the vivid fields of Medical Device Development technology, BioNanoSensors, NanoDiagnostics, NanoAnalytics, Pre-formulation and Formulation of Smart-materials & their applications

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BIO-PHYSIO SENSORS

We develop medical devices for diverse disease diagnostics and therapeutics. The devices that are affordable to the mass population, easy-to-use, and portable, will be made available to be used in remote or resource-limited settings.

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POINT-OF-CARE TECHNIQUES

Our lab has expertise in the development of lateral flow immunoassays and portable electronic devices required for signal processing and analysis. Sensor-based colorimeter, as well as the fluorimeter, have been developed earlier

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NANOBIOTECHNOLOGY

Our lab works on the synthesis of various nanoparticles including semiconductor nanocrystals i.e. Quantum Dots. The biofunctionalization of nanoparticles improves its utility in the development of biosensors.

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Research supported by:

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In this work, we demonstrate label-free electrochemical impedance spectroscopy (EIS) based alkaline phosphatase (ALP) detection using gold nanoparticles (AuNPs), electrochemically engineered Au-nano-Dendroids, and graphene oxide (GO) nanocomposite. These nanomaterials were sequentially deposited on to the screen-printed carbon electrode (SPCE) and antibodies against ALP (anti-ALP) were immobilized using carbodiimide bioconjugation process. The sensor probe has been characterized extensively using TEM, EDX, SAED, XRD, FE-SEM, FTIR, DIC, and electrochemical techniques. The analytical performance of fabricated biosensor has been evaluated using EIS, where linear dynamic range and limit of detection were obtained to be 100–1000 U/L and 9.10 (±0.12) U/L, respectively. The developed biosensor showed high selectivity towards ALP with negligible interference (ksel « 1; n = 3) due to coexisting molecules. The sensor probe has successfully recovered ALP between 108.84% and 172.50% (n = 3) in human serum samples. The sensor has been used to estimate ALP in clinical serum samples, where the level was found to be 83.15 U/L and was comparable with standard technique used in the hospitals. The shelf life, stability, and reproducibility have also been evaluated.

— Kuldeep Mahato, Buddhadev Purohit, Ashutosh Kumar, Pranjal Chandra*

Products

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ALP Detection Kit

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ALP Analyzing Smartphone Application

Available in:

  • Google Play

Google Play

  • Google-Drive-icon

Drive Link

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3D Printed Optical Sensing System

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To be launched